apalutamide will lower the extent or impact of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medicine which have been CYP3A4 substrates may lead to lessen exposure to these medicines.Findings from the few early animal and mobile exp